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Association Of Raised Serum Triglycerides With Incidence Of Pre-Eclampsia

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Shafiq S, Muzaffar S, Qurrat-Ul-Ain, Farooq N, Shams N, Meraj L. Association Of Raised Serum Triglycerides With Incidence Of Pre-Eclampsia . JRMC [Internet]. 2023 Sep. 26 [cited 2024 Dec. 13];27(3). Available from: http://www.journalrmc.com/index.php/JRMC/article/view/2315

Abstract

Background: Pre-eclampsia, a serious multi-systemic pregnancy complication is estimated to occur in 5-10% of pregnancies worldwide.

Objective: To determine the frequency of pre-eclampsia in pregnant females with hyper-triglyceridemia and to study its associations.

Methodology: This Cross-sectional study was conducted at Gynecology Dept. Poly Clinic Hospital, Islamabad (March - Sept. 2022). Pregnant females of age 15-40 years, gestational age 13-20th weeks and singleton pregnancy were included. Known hypertensives, receiving lipid-lowering or anti-hypertensives, chronic kidney or liver disease, teenage pregnancies, primigravida, history of CVA, IHD, epilepsy or endocrine disorders were excluded. After the detailed clinical evaluation, fasting serum triglyceride levels were checked. A total of 225 cases with elevated serum triglycerides were finally selected and evaluated for the presence of pre-eclampsia by monitoring the blood pressure, cardiovascular, gynaecological examination and urine for the presence of proteinuria. Patients were followed till the development of pre-eclampsia or completion of pregnancy.  Results: Among 225 pregnant females with raised serum triglycerides, the mean age was 24.28+5.5 years. Pre-eclampsia was observed in 47(20.89%) of patients.  The Chi-square tests of association between pre-eclampsia and each of parity, residential status, and socio-economic status were insignificant while BMI and Gestational age were significant.  Conclusion: There is a high prevalence of pre-eclampsia in pregnant women with hypertriglyceridemia. Serum triglyceride levels may predict the women at risk for pre-eclampsia. The risk of preeclampsia in women with hyper-triglyceridemia is independent of parity, and socioeconomic or residential status. Hypertriglyceridemia may predispose to pre-eclampsia even at lower BMI levels. The development of hypertriglyceridemia in early gestation may be an additional risk factor. Early screening of women at risk may lead to better outcomes.

https://doi.org/10.37939/jrmc.v27i3.2315

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Copyright (c) 2023 Saima Shafiq, Sara Muzaffar, Qurrat-Ul-Ain, Naushin Farooq , Nadia Shams, Lubna Meraj