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Association Of Raised Serum Triglycerides With Incidence Of Pre-Eclampsia

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Shafiq S, Muzaffar S, Qurrat-Ul-Ain, Farooq N, Shams N, Meraj L. Association Of Raised Serum Triglycerides With Incidence Of Pre-Eclampsia . JRMC [Internet]. 2023 Sep. 26 [cited 2024 May 26];27(3). Available from: http://www.journalrmc.com/index.php/JRMC/article/view/2315

Abstract

Background: Pre-eclampsia, a serious multi-systemic pregnancy complication is estimated to occur in 5-10% of pregnancies worldwide.

Objective: To determine the frequency of pre-eclampsia in pregnant females with hyper-triglyceridemia and to study its associations.

Methodology: This Cross-sectional study was conducted at Gynecology Dept. Poly Clinic Hospital, Islamabad (March - Sept. 2022). Pregnant females of age 15-40 years, gestational age 13-20th weeks and singleton pregnancy were included. Known hypertensives, receiving lipid-lowering or anti-hypertensives, chronic kidney or liver disease, teenage pregnancies, primigravida, history of CVA, IHD, epilepsy or endocrine disorders were excluded. After the detailed clinical evaluation, fasting serum triglyceride levels were checked. A total of 225 cases with elevated serum triglycerides were finally selected and evaluated for the presence of pre-eclampsia by monitoring the blood pressure, cardiovascular, gynaecological examination and urine for the presence of proteinuria. Patients were followed till the development of pre-eclampsia or completion of pregnancy.  Results: Among 225 pregnant females with raised serum triglycerides, the mean age was 24.28+5.5 years. Pre-eclampsia was observed in 47(20.89%) of patients.  The Chi-square tests of association between pre-eclampsia and each of parity, residential status, and socio-economic status were insignificant while BMI and Gestational age were significant.  Conclusion: There is a high prevalence of pre-eclampsia in pregnant women with hypertriglyceridemia. Serum triglyceride levels may predict the women at risk for pre-eclampsia. The risk of preeclampsia in women with hyper-triglyceridemia is independent of parity, and socioeconomic or residential status. Hypertriglyceridemia may predispose to pre-eclampsia even at lower BMI levels. The development of hypertriglyceridemia in early gestation may be an additional risk factor. Early screening of women at risk may lead to better outcomes.

https://doi.org/10.37939/jrmc.v27i3.2315

References

Rana S, Lemoine E, Granger JP, Karumanchi SA. Preeclampsia: Pathophysiology, Challenges, and Perspectives [published correction appears in Circ Res. 2020 Jan 3;126(1):e8]. Circ Res. 2019;124(7):1094-1112. doi:10.1161/CIRCRESAHA.118.313276.

Ngwenya S. Severe preeclampsia and eclampsia: incidence, complications, and perinatal outcomes at a low-resource setting, Mpilo Central Hospital, Bulawayo, Zimbabwe. Int J Womens Health. 2017; 9:353-357. doi:10.2147/IJWH.S131934

Khurshid R, Shamsi A, Fayyaz I, Zia M. Maternal Serum Uric Acid level during pregnancy. A biomarker for preeclampsia. Pak J Med Health Sci. 2016; 10:413-5.

Blencowe H, Cousens S, Jassir FB, Say L, Chou D, Mathers C, et al. National, regional, and worldwide estimates of stillbirth rates in 2015, with trends from 2000: a systematic analysis. Lancet Glob Health. 2016; 4(2):98-108. doi:10.1016/S2214-109X(15)00275-2.

Armaly Z, Jadaon JE, Jabbour A, Abassi ZA. Preeclampsia: Novel Mechanisms and Potential Therapeutic Approaches. Front Physiol. 2018; 9:973-8. doi:10.3389/fphys.2018.00973.

Ives CW, Sinkey R, Rajapreyar I, Tita ATN, Oparil S. Preeclampsia Pathophysiology and Clinical Presentations: JACC State-of-the-Art Review. J Am Coll Cardiol. 2020; 76(14):1690-702. doi:10.1016/j.jacc.2020.08.014.

Peng J, Luo F, Ruan G, Peng R, Li X. Hypertriglyceridemia and atherosclerosis. Lipids Health Dis. 2017;16(1):233-6. doi:10.1186/s12944-017-0625-0.

Joy SB, Islam MR, Khandoker M, Biswas AK. Study on Association of Maternal Triglyceride and Preeclampsia. Faridpur Med Coll J. 2019; 14(2):82-5. https://doi.org/10.3329/fmcj.v14i2.48184.

Thathagari V, Kumar VCM. Evaluation of serum lipids in preeclampsia: a comparative study. Int J Reprod Contracept Obstet Gynecol. 2018; 7:1372-75. doi:10.18203/2320-1770.ijrcog20180998.

Nisar M, Zafar M, Tabbassum A, Mazhar SB. Maternal Serum Triglycerides in Women with Pre-Eclampsia. J. Soc. Obstet. Gynaecol. Pak. 2018; 8(1):24-28.

Avidime AR, Tella MA, Hadiza G, Abiodun OO. A comparative Study of Serum Lipid Levels in PreEclamptic and Normotensive Pregnant Women in a Tertiary Hospital, Northwest Nigeria. J Sci Tech Res. 2018;3:1-5. doi: 10.26717/BJSTR.2018.3.000845.

Mousa MSM, Ahmed A, Omda FA. Maternal Lipid Profile as A Risk Factor for Preeclampsia.” The Egyptian Journal of Hospital Medicine 71 2018: 3434-38.

Xue R, Wu D, Zhou C, Chen L, Li J, Li Z. Association of high maternal triglyceride levels early and late in pregnancy with adverse outcomes: A retrospective cohort study. J Clin Lipidol. 2021;15:162-72. doi:10.1016/j.jacl.2020.10.001.

Rajyalakshmi K, Rao BS. A study of serum lipoproteins and serum triglycerides in normal pregnancy and pregnancy induced hypertension and eclampsia. Int J Contemp Med Res. 2016;3(10):2927-30.

Magley M, Hinson MR. Eclampsia. [Updated 2023 Jan 30]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK554392/.

Tessema, G. A., Tekeste, A. & Ayele, T. A. Preeclampsia and associated factors among pregnant women attending antenatal care in Dessie referral hospital, Northeast Ethiopia: A hospital-based study. BMC Preg Childbirth 2015: 15:1–7. doi:10.1186/s12884-015-0502-7.

Das R, Biswas S. Eclapmsia: The Major Cause of Maternal Mortality in Eastern India. Ethiop J Health Sci. 2015 Apr; 25(2):111-6. doi: 10.4314/ejhs.v25i2.2.

Mou AD, Barman Z, Hasan M, Miah R, Hafsa JM, Das Trisha A, Ali N. Prevalence of preeclampsia and the associated risk factors among pregnant women in Bangladesh. Sci Rep. 2021;11(1):21339. doi: 10.1038/s41598-021-00839-w.

Belay AS, Wudad T. Prevalence and associated factors of pre-eclampsia among pregnant women attending anti-natal care at Mettu Karl referral hospital, Ethiopia: Cross-sectional study. Clin. Hypertens. 2019; 25:1–8. doi:10.1186/s40885-019-0120-1.

Thakur V, Thakur A, Saroshe S. Comparison of the effect of nifedipine, labetalol and methyldopa in treatment of hypertension in pregnancy in a tertiary care government hospital. Int J Reproduct, Contracept, Obstetr Gynecol. 2016;5(1):17-22. doi: 10.18203/2320-1770.ijrcog20151495.

Tolcher MC, Fox KA, Sangi-Haghpeykar H, Clark SL, Belfort MA. Intravenous labetalol versus oral nifedipine for acute hypertension in pregnancy: effects on cerebral perfusion pressure. Am J Obstet Gynecol. 2020;223(3):441.e1-441.e8. doi:10.1016/j.ajog.2020.06.018.

Bisson C, Dautel S, Patel E, Suresh S, Dauer P, Rana S. Preeclampsia pathophysiology and adverse outcomes during pregnancy and postpartum. Front Med (Lausanne). 2023 Mar 16;10:1144170. doi: 10.3389/fmed.2023.1144170.

Vata PK, Chauhan NM, Nallathambi A, Hussein F. Assessment of prevalence of preeclampsia from Dilla region of Ethiopia. BMC Res Notes. 2015;8:816. doi:10.1186/s13104-015-1821-5.

Agrawal S, Walia GK. Prevalence and Risk Factors for Symptoms Suggestive of Pre-Eclampsia in Indian Women. J Womens Health, Issues Care 2014; 3:6. doi:10.4172/2325-9795.1000169.

Umesawa M, Kobashi G. Epidemiology of hypertensive disorders in pregnancy: prevalence, risk factors, predictors and prognosis. Hypertens Res. 2017;40(3):213-20. doi:10.1038/hr.2016.126.

Abalos E. Pre-eclampsia, eclampsia and adverse maternal and perinatal outcomes: A secondary analysis of the World Health Organization Multicountry Survey on Maternal and Newborn Health. BJOG. 2014;121(Suppl):14–24. doi:10.1111/1471-0528.12629.

Ray JG, Diamond P, Singh G, Bell CM. Brief overview of maternal triglycerides as a risk factor for pre-eclampsia. BJOG. 2006;113(4):379-86. doi:10.1111/j.1471-528.2006.00889.x.

Tesfa E, Nibret E, Munshea A. Maternal lipid profile and risk of preeclampsia in African pregnant women: A systematic review and meta-analysis. PLoS ONE 2020;15(12): e0243538. doi:10.1371/journal.pone.0243538.

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Copyright (c) 2023 Saima Shafiq, Sara Muzaffar, Qurrat-Ul-Ain, Naushin Farooq , Nadia Shams, Lubna Meraj