Correlation of Molecular Subtypes with Clinico Correlation of Molecular Subtypes with Clinico Correlation of Molecular Subtypes with Clinico Correlation of Molecular Subtypes with Clinico Correlation of Molecular Subtypes with ClinicoCorrelation of Molecu

Aisha Akbar; Ghazala Mudassir; Mariam Abid; Hania Naveed; Mahwish Majeed

Aisha Akbar Department of Pathology, Shifa College of Medicine, Islamabad
Ghazala Mudassir Department of Pathology, Shifa College of Medicine, Islamabad
Mariam Abid Department of Pathology, Shifa College of Medicine, Islamabad
Hania Naveed Department of Pathology, Shifa College of Medicine, Islamabad
Mahwish Majeed Department of Pathology, Shifa College of Medicine, Islamabad

Keywords: Carcinoma breast, Molecular Subtypes, Estrogen receptor, progesterone receptor, Human epidermal growth factor receptor

Abstract

Background:ckground: ckground:ckground: To determine the correlation between clinic-pathological parameters, like age of the patient, size of the tumour, histologic type and grade with molecular subtype.
Methods : Methods : Methods : Methods : Methods : Methods : This observational study included cases of breast cancer (n=50) . Histological grade was assessed according to Nottingham modification of Bloom-Richardson system. Representative sections with tumour and the adjacent normal tissue ( internal control) were processed for ER, PR and HER-2neu immune-histochemical staining. The scoring of ER and PR was carried out using Allred scoring system. Molecular subtypes were defined as, triple negative/basal type(HER 2 -,ER- and PR-), hormone receptor(HR) +,HER2-/luminal A(HER2-, ER+ and PR+ or -), HR+,HER2+/luminal B(HER2 +,ER+ and PR+ or-), HR-,HER2+/HER2 enriched(HER2+, ER- and PR -).
Results Results Results : Majority (96%) were infiltrating ductal carcinoma, one was invasive lobular carcinoma and one was colloid carcinoma. Three cases (6%) grade 1 carcinoma were recorded of which one case (2%) each was of luminal A, luminal B and HER2 enriched type. There were 23 (46%) grade 2 cases of which 8(16%) were luminal A, 7(14%) of luminal B, 7(14%) of HER2 enriched and one (2%) was basal like. There were 24(48%) grade 3 cases of which 6(12%) were luminal A, 9(18%) of luminal B, 6(12%) were HER2 enriched and 4(8%) were basal like.
Conclusion: Conclusion: Conclusion:Conclusion: Along with other variables, molecular subtype is important in predicating prognosis of carcinoma breast .Luminal A cancers are more common in older age, while Luminal B are common in younger age group.