Relationship Between Serum Lactate Dehydrogenase Levels and Dengue Severity

Abstract

To determine relationship between
the levels of serum Lactate Dehydrogenase (LDH)on
admission and prognosis of dengue fever.
Methods: Patients (n=62) admitted with the
diagnosis of dengue fever were included. On
admission, serum LDH levels were measured in all
patients and to find relationship we monitored all
patients upto discharge. Monitoring was done for
vitals, different blood parameters and duration of
hospitalization.
Results: Forty one (66.1%) were males and 33.9%
(n=21) were females with mean age
31.73±13years.During hospital stay, 61.3% patients
had Dengue fever (DF)while 39.7% patients
developed dengue hemorrhagic fever (DHF).LDH
levels were higher in patients with DHF(mean
618.38U/L±219)as compared to the patients with
dengue fever (mean 316.45U/L±104).Mann Whitney
U test showed the difference was statistically
significant (p<0.001).
Conclusion: Patients with early increase in serum
LDH showed more complications as compared to
low serum LDH level. High LDH can be used to
predict outcome in dengue patients.