Supplementary Files
How to Cite
Abstract
Objective: The objective of this study was to determine the efficacy of bovine colostrum for the treatment of acute diarrhoea among infants and children admitted to a tertiary care hospital in Islamabad, Pakistan.
Methods: This interventional study was conducted at a tertiary care hospital, Islamabad. Infants and children admitted to the hospital with acute diarrhoea were selected through consecutive sampling. Group A received bovine colostrum along with the standard treatment, whereas group B received standard treatment alone. Number of days to achieve defecation frequency of <3 Times per day, normal stool consistency, and duration of hospital stay were the main outcomes of interest. SPSS version 21 was used for statistical analysis.
Result: Mean recovery time in Group A was 1.4865+ 0.506 days and in Group B was 1.2174 + days. The mean number of days remaining for patients admitted in Group A was 3.8919 + 1.629 days, while in Group B it was 3.8261+ 1.64 days. The efficacy was 33.59 in group A, while 25.52 in group B. This difference was not statistically significant (p=0.738).
Conclusion: There was no difference between the group taking standard treatment and the one taking standard treatment plus bovine colostrum in terms of recovery time and efficacy but the difference was significant in terms of the number of days patients remained admitted where bovine colostrum group had increased no of days of admission so conclusion is there is not much role of bovine colostrum in treatment of acute diarrhea when combined with standard care.
References
Ugboko HU, Nwinyi OC, Oranusi SU, Oyewale JO. Childhood diarrhoeal diseases in developing countries. Heliyon. 2020 Apr 13;6(4):e03690. https://doi.org/10.1016/j.heliyon.2020.e03690. Erratum in: Heliyon. 2020;6(6):e04040.
Barakat SH, Meheissen MA, Omar OM, Elbana DA. Bovine colostrum in the treatment of acute diarrhoea in children: A double-blinded randomised controlled trial. Journal of Tropical Pediatrics. 2020 Feb;66(1):46-55. https://doi.org/10.1093/tropej/fmz029
Yu M, Jin X, Liang C, Bu F, Pan D, He Q,et al. Berberine for diarrhea in children and adults: a systematic review and meta-analysis. Therapeutic Advances in Gastroenterology. 2020 Oct; 13:1756284820961299.
Claudine U, Kim JY, Kim EM, Yong TS. Association between sociodemographic factors and diarrhea in children under 5 years in Rwanda. The Korean journal of parasitology. 2021 Feb;59(1):61. https://doi.org/10.3347/kjp.2021.59.1.61
Bardhan PK, Das R, Nahar B, Haque MA, Sobi RA, Sultana AA, et al. Assessing safety and efficacy of a novel glucose-free amino acid oral rehydration solution for watery diarrhea management in children: a randomized, controlled, phase III trial. Eclinicalmedicine. 2024 Jun 1;72.
Huang R, Xing HY, Liu HJ, Chen ZF, Tang BB. Efficacy of probiotics in the treatment of acute diarrhea in children: a systematic review and meta-analysis of clinical trials. Transl Pediatr. 2021;10(12):3248-3260. https://doi.org/10.21037/tp-21-511.
Szajewska H, Kołodziej M, Zalewski BM. Systematic review with meta-analysis: Saccharomyces boulardii for treating acute gastroenteritis in children-a 2020 update. Aliment Pharmacol Ther. 2020;51(7):678-688. https://doi.org/10.1111/apt.15659.
Barakat SH, Meheissen MA, Omar OM, Elbana DA. Bovine Colostrum in the Treatment of Acute Diarrhea in Children: A Double-Blinded Randomized Controlled Trial. J Trop Pediatr. 2020;66(1):46-55. https://doi.org/10.1093/tropej/fmz029.
Playford RJ, Weiser MJ. Bovine colostrum: Its constituents and uses. Nutrients. 2021 Jan 18;13(1):265. https://doi.org/10.3390/nu13010265
Chandwe K, Kelly P. Colostrum Therapy for Human Gastrointestinal Health and Disease. Nutrients. 2021;13(6):1956. https://doi.org/10.3390/nu13061956.
Yalçıntaş YM, Duman H, Rocha JM, Bartkiene E, Karav S, OZOGUL F. Role of bovine colostrum against various diseases. Food Bioscience. 2024 Aug 2:104818. https://doi.org/10.1016/j.fbio.2024.104818
Hajihashemi P, Haghighatdoost F, Kassaian N, Rahim Khorasani M, Hoveida L, Nili H, Tamizifar B, Adibi P. Therapeutics effects of bovine colostrum applications on gastrointestinal diseases: a systematic review. Systematic Reviews. 2024 Feb 26;13(1):76. https://doi.org/10.1186/s13643-024-02489-1.
Suwarba IG, Sudaryat S, Hendra S, Suandi IK, Widiana R. The role of bovine colostrum on recovery time and length of hospital stay of acute diarrhea in infants and children: a double-blind randomized controlled trial. Paediatr Indones. 2006;46(3):127-33.
Sangild PT, Vonderohe C, Melendez Hebib V, Burrin DG. Potential Benefits of Bovine Colostrum in Pediatric Nutrition and Health. Nutrients. 2021 Jul 26;13(8):2551. https://doi.org/10.3390/nu13082551.
Chandwe K, Kelly P. Colostrum Therapy for Human Gastrointestinal Health and Disease. Nutrients. 2021 Jun 7;13(6):1956. https://doi.org/10.3390/nu13061956.
Sadeghirad B, Morgan RL, Zeraatkar D, Zea AM, Couban R, Johnston BC, Florez ID. Human and Bovine Colostrum for Prevention of Necrotizing Enterocolitis: A Meta-analysis. Pediatrics. 2018 Aug;142(2):e20180767. https://doi.org/10.1542/peds.2018-0767.
Barakat NM. Gut priming with bovine colostrum and T regulatory cells in preterm neonates: a randomized controlled trial. Pediatr Res. 2021 Sep;90(3):650-656. https://doi.org/10.1038/s41390-020-01344-y.
Halasa M, Zydecka KS, Machalinski B,Buhner L, Halasa MB.Six Weeks of Supplementation with Bovine Colostrum Effectively Reduces URTIs Symptoms Frequency and Gravity for Up to 20 Weeks in Pre-School Children. Nutrients. 2023 Aug 18;15(16):3626. https://doi.org/10.3390/nu15163626
Li J, Xu YW, Jiang JJ, Song QK. Bovine colostrum and product intervention associated with relief of childhood infectious diarrhea. Scientific Reports. 2019 Feb 28;9(1):3093. https://doi.org/10.1038/s41598-019-39644-x
Linehan K, Ross RP, Stanton C. Bovine colostrum for veterinary and human health applications: A critical review. Annual Review of Food Science and Technology. 2023 Mar 27;14(1):387-410. https://doi.org/10.1146/annurev-food-060721-014650
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Copyright (c) 2025 Hira Hameed, Aummara Rafique, Nadia Tariq, Rubina Zulfiqar, Sohail Aslam, Ainur Zholdabeskova