Official publication of Rawalpindi Medical University
Comparison of Intra-articular Platelet Rich Plasma versus Corticosteroid Injections for the Treatment of Moderate Knee Osteoarthritis

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Keywords

Corticosteroids, intra-articular injections, knee osteoarthritis, knee pain, osteoarthritis, platelet rich plasma, prednisolone acetate.

How to Cite

1.
Napar AR, Solangi NA, Shahni MA, Ghumro H, Jumani NA, Hussain A. Comparison of Intra-articular Platelet Rich Plasma versus Corticosteroid Injections for the Treatment of Moderate Knee Osteoarthritis. JRMC [Internet]. 2023 Apr. 1 [cited 2024 Mar. 29];27(1). Available from: https://www.journalrmc.com/index.php/JRMC/article/view/2016

Abstract

Objective:  To compare the efficacy of intra-articular injections of prednisolone acetate and platelet rich plasma in cases of moderate knee osteoarthritis.

Study design: Prospective comparative study.

Place and Duration of study: Department of Orthopedic Surgery, Khairpur Medical College, Khairpur Mirs, from January 2021 till December 2021

Methodology: A total of 100 patients were selected for the study and were randomly divided into two equal groups. Group C patients received intra-articular corticosteroid injection along with local anesthetic (Prednisolone acetate 40 mg + 3 ml of 0.5% bupivacaine) under ultrasound guidance. Group P patients received 3 injections of PRP, each of 8 ml volume given at one week’s interval. Patients with signs of hemodynamic compromise, sepsis, past history of any intra-articular injection in the same joint were also excluded from the study. Follow up of patients was carried out at 1, 3 and 6 months. The Western Ontario and McMaster Universities Osteoarthritis (WOMAC) scale was used to assess the patients prior to injection and then at each follow up. WOMAC scale consists of three subsets i-e pain, stiffness and physical function.

Results: Demographic data was comparable between both groups. Pre-injection WOMAC score in group C and P was 71.54±12.18 and 75.20±8.58 respectively (p-value=0.086); after one month of injections, it was 34.20±10.48 and 35.38±6.31 respectively (p-value=0.580). After 3 months of injection, it was 33.20±8.13 and 31.10±5.50 respectively (p-value=0.195). After 6 months of injection, it was 35.32±10.41 and 32.10±6.63 respectively (p-value=0.68).

Conclusion: It is concluded in our study that intra-articular injections of prednisolone acetate and PRP are equally effective in patients of moderate knee osteoarthritis.

 

https://doi.org/10.37939/jrmc.v27i1.2016

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Copyright (c) 2023 Abdul Rasheed Napar, Naveed Ahmed Solangi, Mehtab Shahni, Hafeezullah Ghumro, Naveed Ahmed Jumani, Aftab Hussain