Official publication of Rawalpindi Medical University
Hepcidin Levels in Multi Transfused β Thalassemia Major Patients
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1.
MuhammadJawad, Iram Aftab , Muhammad Tahir Saeed, Ghazala Mumtaz , Saima Iram , Shahida Mohsin. Hepcidin Levels in Multi Transfused β Thalassemia Major Patients. JRMC [Internet]. 2016 Sep. 30 [cited 2024 Mar. 29];20(3). Available from: https://www.journalrmc.com/index.php/JRMC/article/view/176

Abstract

Background: To determine and compare the
serum hepcidin levels and conventional markers of
iron status in patients of β- thalassaemia major with
controls.
Methods: Forty patients of β- thalassaemia major
who were not on iron chelation therapy and 40
normal controls were included in this study.
Hemoglobin level, red blood cell count and
hematocrit of the study group were determined.
Hepcidin levels along with serum iron, serum
ferritin and total iron binding capacity were
determined .
Results:Serum hepcidin level was found to be
reduced in patients (426.21 pg/ml) as compared to
controls (757.45 pg/ ml).
Conclusion: Determination of hepcidin
concentration is a useful indicator for high risk of
iron toxicity in patients of beta thalassaemia with
multiple transfusions

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