Effect of Age and Sex on Left Atrial and Left Ventricular Diastolic Diameters in Patients with Mild Diastolic Dysfunction (Grade I)

Abstract

Background: To analyze the relationship between age, sex, left atrial and left ventricular diastolic diameters in patients with mild diastolic dysfunction.
Methods: In this cross-sectional observational study patients (n=434) diagnosed with mild or grade 1 diastolic dysfunction on Pulse Wave Doppler Echocardiography (E/A<0.8, E/e’<8, abnormal DT) were included. Patients with valvular abnormalities and pericarditis were excluded. Diastolic left atrial and ventricular sizes were determined on echocardiography as per guidelines.
Results:Sex did not show any significant correlation with left atrial and left ventricular diameters (p>0.05). Age was having moderate correlation with left atrial diameter (r=0.49). Age was having negative correlation with left ventricular diameter (r=-0.29) and this was statistically significant (p<0.01). On linear regression analysis, age was the only statistically significant variable that had an un-standardized beta coefficient (B) of 0.207 for left atrial diameter, and -0.7 for left ventricular diameter.
Conclusion:Age was significantly correlated with left atrial and left ventricular diastolic diameters in patients with grade 1 diastolic dysfunction while sex was not statistically significant. On linear regression, age was the only significant factor in predicting left atrial and left ventricular diastolic diameter