Quality of Life in Children with Epilepsy in Wah Cantt, Pakistan: A Cross-sectional Study

  • Shahzad Haider Wah Medical College
  • Tahir Mahmood
  • Sajjad Hussain
  • Sajid Nazir
  • Sidra Shafiq
  • Alina Hassan
Keywords: Children, Epilepsy, Quality of life (QOL), QOL questionnaire.

Abstract

Objective: To assess the Quality Of Life (QOL) in children with epilepsy using modified QOLCE-55 questionnaire.

Material and Methods: We consecutively enrolled children aged 4 to 16 years who were under treatment for childhood epilepsy. Basic demographic and clinical details including type of epilepsy, developmental history, family history of epilepsy and any co-morbidity were recorded in a predesigned Performa. QOL was evaluated by using modified QOLCE-55 (39 items) from parents.

Results: A total of 54 children were enrolled in the study, 42 (78%) were males and 12(22%) were female children with epilepsy.  Eight children got good QOLCE score, while 24 children had average and 22 children got a poor score. The good score was mostly seen in 4-8 years (40%) of age while the poor score was seen in 12-16 years (70%) age group. Age of the patients (p=<0.001), gender (p=<0.001), associated co-morbidities (p=0.003) and family history of epilepsy (p=0.011) showed a significant effect on the QOLCE score. Type of epilepsy (p= 0.825) and development of a child (p=0.109) did not affect the QOLCE score significantly.

Conclusion: The study showed that Children with co-morbidities, family history of epilepsy and female children of older age group (12-16 years) had poor QOL. Types of seizures and development of the child did not significantly alter the QOLCE score.

References

1. Sabaz M, Lawson JA, Cairns DR, Duchowny MS, Resnick TJ, Dean PM, Bye AM. Validation of the quality of life in childhood epilepsy questionnaire in American epilepsy patients. Epilepsy & Behavior. 2003 Dec 1;4(6):680-91. https://doi.org/10.1016/j.yebeh.2003.08.012
2. Goodwin SW, Lambrinos AI, Ferro MA, Sabaz M, Speechley KN. Development and assessment of a shortened Q uality of L ife in C hildhood E pilepsy Q uestionnaire (QOLCE‐55). Epilepsia. 2015 Jun;56(6):864-72. https://doi.org/10.1111/epi.13000
3. Ferro MA, Goodwin SW, Sabaz M, Speechley KN. Measurement equivalence of the newly developed Quality of Life in Childhood Epilepsy Questionnaire (QOLCE‐55). Epilepsia. 2016 Mar;57(3):427-35. https://doi.org/10.1111/epi.13296
4. Conway L, Widjaja E, Smith ML, Speechley KN, Ferro MA. Validating the shortened Quality of Life in Childhood Epilepsy Questionnaire (QOLCE‐55) in a sample of children with drug‐resistant epilepsy. Epilepsia. 2017 Apr;58(4):646-56. https://doi.org/10.1111/epi.13697
5. Nadkarni J, Jain A, Dwivedi R. Quality of life in children with epilepsy. Annals of Indian Academy of Neurology. 2011 Oct;14(4):279. doi: 10.4103/0972-2327.91948
6. Monir ZM, EL-Alameey IR, Eltahlawy E. Health related quality of life of children with epilepsy in Egypt. Journal of The Arab Society for Medical Research. 2013 Jul 1;8(2):53. DOI: 10.4103/1687-4293.123787
7. Stevanovic D. Health-related quality of life in adolescents with well-controlled epilepsy. Epilepsy & behavior. 2007 Jun 1;10(4):571-5. https://doi.org/10.1016/j.yebeh.2007.02.015
8. Arya V, Gehlawat VK, Kaushik JS, Gathwala G. Assessment of parent reported quality of life in children with epilepsy from Northern India: A cross-sectional study. Journal of pediatric neurosciences. 2014 Jan;9(1):17. doi: 10.4103/1817-1745.131473
9. Sabaz M, Lawson JA, Cairns DR, Duchowny MS, Resnick TJ, Dean PM, Bleasel AF, Bye AM. The impact of epilepsy surgery on quality of life in children. Neurology. 2006 Feb 28;66(4):557-61. DOI: https://doi.org/10.1212/01.wnl.0000197788.38783.09
10. Purusothaman V, Ryther RC, Bertrand M, Harker LA, Jeffe DB, Wallendorf M, Smyth MD, Limbrick DD. Developing the pediatric refractory epilepsy questionnaire: a pilot study. Epilepsy & Behavior. 2014 Aug 1;37:26-31. https://doi.org/10.1016/j.yebeh.2014.04.025
11. Sajobi TT, Speechley KN, Liang Z, Goodwin SW, Ferro MA, Wiebe S. Response shift in parents' assessment of health-related quality of life of children with new-onset epilepsy. Epilepsy & Behavior. 2017 Oct 1;75:97-101. https://doi.org/10.1016/j.yebeh.2017.07.015
12. DIN NC. Neuropsychology of Epilepsy in Malaysia: A Narrative Review. Jurnal Sains Kesihatan Malaysia (Malaysian Journal of Health Sciences). 2019 Jun 27;17(2). DOI : http://dx.doi.org./10.17576/JSKM-2019-1702-11
13. Williams J, Steel C, Sharp GB, et al. Parental anxiety and quality of life in children with epilepsy. Epilepsy Behav 2003; 4:483-486
14. Matthews WS, Barabas G, Ferrari M. Emotional concomitants of childhood epilepsy. Epilepsia. 1982 Dec;23(6):671-81. https://doi.org/10.1111/j.1528-1157.1982.tb05083.x
15. Ettinger AB, Weisbrot DM, Nolan EE, Gadow KD, Vitale SA, Andriola MR, Lenn NJ, Novak GP, Hermann BP. Symptoms of depression and anxiety in pediatric epilepsy patients. Epilepsia. 1998 Jun;39(6):595-9. https://doi.org/10.1111/j.1528-1157.1998.tb01427.x
16. Hoare P, Mann H. Self-esteem and behavioural adjustment in children with epilepsy and children with diabetes. Journal of Psychosomatic Research. 1994 Nov 1;38(8):859-69. https://doi.org/10.1016/0022-3999(94)90073-6
17. Gutierrez-Angel AM, Martinez-Juarez IE, Hernandez-Vanegas LE, Crail-Melendez D. Quality of life and level of burden in primary caregivers of patients with epilepsy: effect of neuropsychiatric comorbidity. Epilepsy & Behavior. 2018 Apr 1;81:12-7. https://doi.org/10.1016/j.yebeh.2018.01.034
18. Pratt HD. Interpersonal violence, aggression, and antisocial behaviours in the adolescents. The Indian Journal of Pediatrics. 1999 Jul 1;66(4):589-602.
19. Fastenau PS, Shen J, Dunn DW, Austin JK. Academic underachievement among children with epilepsy: proportion exceeding psychometric criteria for learning disability and associated risk factors. Journal of learning disabilities. 2008 May;41(3):195-207. https://doi.org/10.1177/0022219408317548
20. Ibekwe RC, Ojinnaka NC, Iloeje SO. Factors influencing the academic performance of school children with epilepsy. Journal of tropical pediatrics. 2007 Oct 1;53(5):338-43. https://doi.org/10.1093/tropej/fmm034
Published
2020-06-26
How to Cite
1.
Haider S, Mahmood T, Hussain S, Nazir S, Shafiq S, Hassan A. Quality of Life in Children with Epilepsy in Wah Cantt, Pakistan: A Cross-sectional Study. JRMC [Internet]. 26Jun.2020 [cited 22Oct.2020];24(2):128-33. Available from: https://www.journalrmc.com/index.php/JRMC/article/view/1232
Section
Articles

Most read articles by the same author(s)