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Abstract
To study the effect of high dose
ginger on plasma testosterone and leutinising
hormone levels in male rats after lead induced
toxicity
Methods: In this quasi experimental study, 30
adult male Sprague Dawley rats were divided in two
equal groups. Group A was given 0.3% lead acetate
in drinking water and kept as lead control while the
Group B was given a dose of 1.5gm/kg body weight
ginger orally along with 0.3% lead for 42 consecutive
days. Rats were then sacrificed and serum
testosterone and LH levels were analyzed using
ELISA technique. Data was expressed as mean±SD.
P-values <0.05 were considered as statistically
significant.
Results: At the end of 42 days, mean serum
testosterone level in Group A (control Group) was
2.2667± 0.45617ng/ml as compared to Group B
(Experimental Group) 2.2667 ± 0.45617ng/ml and
showed statistically insignificant change(p>0.05).
Comparison of mean serum LH levels in Group A
(5.3200 ± 0.72526ng/ml)revealed statistically
insignificant difference (p>0.05) as compared to
Group B (5.7467 ± 0.70190ng/ml).
Conclusion: High dose ginger (>1gm/kg body
weight) failed to enhance the suppressed
testosterone level due to lead toxicity in male rats