TY - JOUR AU - Moazzam, Sadia AU - Mughal, Irfan Afzal AU - Irfan, Noor Ul Ain AU - Attique, Ilqa AU - Zaheer, Fareeha AU - Irfan, Asma PY - 2023/04/02 Y2 - 2024/03/29 TI - Effect of chronic restraint stress on body weight of male Sprague Dawley rats JF - Journal of Rawalpindi Medical College JA - JRMC VL - 27 IS - 1 SE - Articles DO - 10.37939/jrmc.v27i1.1848 UR - http://www.journalrmc.com/index.php/JRMC/article/view/1848 SP - AB - <p><strong><span data-contrast="auto">Background:</span></strong><span data-ccp-props="{}"> </span></p><p><span data-contrast="none">Stress disturbs body weight and food intake, but the core mechanisms are not well understood.</span><span data-ccp-props="{}"> </span></p><p><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335559740&quot;:360}"> </span></p><p><strong><span data-contrast="auto">Study design</span></strong><span data-contrast="auto">:  Experimental </span><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335559740&quot;:360}"> </span></p><p><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335559740&quot;:360}"> </span></p><p><strong><span data-contrast="auto">Materials and Methods:</span></strong><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335559740&quot;:360}"> </span></p><p><span data-contrast="auto">The study was conducted in  National  Institute  of  Health  (NIH),  Islamabad Sixty male Sprague Dawley rats (mean wt 250 ± 50 grams) were used and divided into 2 groups. </span><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335559740&quot;:360}"> </span></p><p><span data-contrast="auto">Each group comprised of 30 rats. </span><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335559740&quot;:360}"> </span></p><p><span data-contrast="auto">Group I was taken as control. Group II was exposed to chronic stress.</span><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335559740&quot;:360}"> </span></p><p><strong><span data-contrast="auto">Results</span></strong><span data-contrast="auto">:</span><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335559740&quot;:360}"> </span></p><p><span data-contrast="auto">The comparison of weight gain by the different groups disclosed that there was a significant decrease in weight gain of rats exposed to the chronic stress as compared to control group. </span><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335559740&quot;:360}"> </span></p><p><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335559740&quot;:360}"> </span></p><p><strong><span data-contrast="auto">Conclusion:</span></strong><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335559740&quot;:360}"> </span></p><p><span data-contrast="auto">Chronic restraint stress has a detrimental effect on body weight. </span><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335559740&quot;:360}"> </span></p> ER -