TY - JOUR AU - Maryam Mushtaq, Humaira Rizwan, Shermeen Kousar, Ayesha Akram, Samina Irshad, Nasim Irshad, PY - 2021/06/30 Y2 - 2024/03/29 TI - Comparison of the Effect of Administration Time of Prophylactic Antibiotics on Post-Operative Wound Infection after Caesarean Section JF - Journal of Rawalpindi Medical College JA - JRMC VL - 25 IS - 2 SE - Articles DO - 10.37939/jrmc.v25i2.1596 UR - http://www.journalrmc.com/index.php/JRMC/article/view/1596 SP - AB - <p><strong>Objective: </strong>To compare the post-operative wound infection rate after cesarean section in women receiving prophylactic antibiotics before skin incision with women receiving antibiotic after cord clamping of baby.</p><p><strong>Study design: </strong>Randomized controlled trial</p><p><strong>Place and Duration of Study:</strong> &nbsp;Department of Obstetrics and Gynecology, Holy Family hospital, Rawalpindi from October 2017 to April 2018.</p><p><strong>Materials &amp; Methods: </strong>356 patients pregnant female of age 20-45 years who were at term undergoing elective cesarean section for any indication were enrolled. All the patients were randomly divided into two groups. Group A (study group) was comprised of patients who received prophylactic antibiotic dose 15-60 min before the start of surgery. Group B (control group) was comprised of patients who received the antibiotic after the cord clamping of the baby. &nbsp;The wound infection was noted for both the groups. All the patients were followed up for 8 days to assess infection. Data was analyzed using SPSS version 22.&nbsp;</p><p><strong>Results: </strong>Mean maternal age of the total study population found to be 28.6±5.3 years. Mean gestational age in all the enrolled patients found to be 37.7±1.2 weeks. Wound infection was noted in 28.4% (n=101) of total study population. Out of 101 total patients who presented with wound infection, 63 patients (62.4%) were of control group while only 38 (37.6%) patients belonged to study group. The difference was statistically significant (<em>P</em>&lt;0.05).</p><p><strong>Conclusions:</strong> Prophylactic antibiotic are useful for controlling post cesarean wound infection.</p><p><strong>KEY WORDS: </strong>Cesarean delivery, Ceftriaxone, Wound infection</p> ER -