TY - JOUR AU - Surwaich Ali Channa,Arhama Surwaich,Muhammad Muslim Khahro, Uzma Tariq, Waqas Iqbal,, Surwaich Ali Channa,Arhama Surwaich,Muhammad Muslim Khahro, Uzma Tariq, Waqas Iqbal, PY - 2019/05/02 Y2 - 2024/03/28 TI - Methylene Blue and Lugol’s Iodine as an Adjunctive Tool for Early Diagnosis of Premalignant Oral Lesions JF - Journal of Rawalpindi Medical College JA - JRMC VL - 23 IS - 2 SE - Articles DO - UR - http://www.journalrmc.com/index.php/JRMC/article/view/1107 SP - AB - <p>Objective: To compare Methylene blue and <br>Lugol’s Iodine as6an adjunctive tool6for early <br>diagnosis of premalignant oral6lesions by taking <br>histopathology as gold standard. <br>Methods: In this cross-sectional study patients of <br>oral0premalignant lesions were selected. Methylene <br>blue and lugols iodine staining was used at lesion’s <br>area. Mucosa0of target site was dried gently by <br>gauze0and power0air0spray with triple syringe to <br>make sure that the0lesion is not0being contaminated <br>with0saliva. The dye was applied directly with a <br>cotton0bud for 10-20 seconds and was decolorized. <br>The dye retention pattern was evaluated by stain <br>retention’s intensity on the lesion. Incisional biopsy <br>was performed simultaneously from that site as gold <br>standard. <br>Results: Out of 60 cases, males were 81.6%. <br>Majority (65.0%) had more than one addicting habit <br>of mainpuri, gutka and supari. The commonest <br>region of oral lesions was the buccal6mucosa <br>(61.6%). According to the diagnostic accuracy of <br>methylene blue the sensitivity was 89.4% and <br>specificity was 66.6%. According to the Lugol’s <br>Iodine sensitivity was 83.3% and specificity was <br>50%. <br>Conclusion: Methylene blue and lugols iodine <br>staining are an easy and non-invasive screening tools <br>for the early diagnosis of malignancy.</p> ER -