@article{Taimur Khalil Sheikh, Rubina Zulfiqar, Tariq Mahmood_2018, title={Diagnostic Accuracy of Umbilical Cord Bilirubin Measurement in Development of Significant Hyperbilirubinemia in Healthy Neonates}, volume={22}, url={http://www.journalrmc.com/index.php/JRMC/article/view/842}, abstractNote={<p>Background: To determine the diagnostic accuracy<br>of umbilical cord blood bilirubin in determining the<br>development of significant hyperbilirubinemia on<br>the 3rd day of life in healthy full term newborns,<br>keeping serum bilirubin as a gold standard.<br>Methods: In this cross sectional study babies<br>delivered consecutively were taken.Any condition<br>which can aggravate hyperbilirubinemia and any<br>patient with congenital abnormality were excluded.<br>Cord blood sample was collected from the neonatal<br>end of the umbilical cord after it had been cut and<br>investigated for serum total bilirubin (STB).<br>Venous sample was taken on the 3rd day of life and<br>sent for serum total bilirubin. Babies were then<br>discharged or admitted for treatment depending on<br>their serum total bilirubin levels. Mean serum total<br>bilirubin in cord blood and mean total serum<br>bilirubin on 3rd day of life was calculated. A 2 x 2<br>table was constructed to determine sensitivity,<br>specificity positive and negative predictive values.<br>Results: The mean cord STB was 2.0 mg/dl ± 0.6.<br>Out of the 115 babies, 26% developed significant<br>hyperbilirubinemia requiring phototherapy, only<br>one needed exchange transfusion. The results<br>showed that cord blood bilirubin ≥2.5mg/dl had the<br>high sensitivity (87%) and specificity (98%) to<br>predict the newborn that would develop significant<br>hyperbilirubinemia. At this level the negative<br>predictive value was 95%. The diagnostic accuracy of<br>cord bilirubin 94.8%.<br>Conclusion: A cord blood STB of ≥2.5md/dl is<br>predictive of significant hyperbilirubinemia on the<br>3rd day of life in healthy neonates</p>}, number={1}, journal={Journal of Rawalpindi Medical College}, author={Taimur Khalil Sheikh, Rubina Zulfiqar, Tariq Mahmood}, year={2018}, month={Mar.} }