How to Cite
Abstract
Background: To compare Endoscopic Retrograde
Cholangio Pancreatography (ERCP) sedation
receiving propofol alone and with midazolam in
terms of mean propofol dosage and mean recovery
time.
Methods: In this comparative study, patients
undergoing therapeutic ERCP were divided into
Group A (Propofol alone) and Group B (Propofol
plus Midazolam). Mean propofol dose adjusted to
weight and duration of procedure and mean recovery
time was compared between the two groups.
Results: There were 40 patients in each group;
46.3% (n=37) males and 53.8% (n=43) females.
According to ASA class stratification, 43% (n=34)
patients were in ASA class I, 41% (n=33) patients in
ASA class II and 16% (n=13) patients in ASA class
III. The mean dose of propofol was not significantly
different between the two groups; 276 ± 124 mg
(Group A) vs. 290 ± 115 mg (Group B), p=0.58). The
mean adjusted dose when adjusted to weight and
duration of procedure also did not significantly
differ; 0.08 ± 0.04 (Group A) vs. 0.07 ± 0.03 (Group B),
p= 0.38). The recovery time was significantly better
with propofol monotherapy; 12 ± 7 min (Group A)
vs. 44 ± 13 min (Group B), p=0.0001).
Conclusion: In comparison to sedation with
propofol and midazolam in ERCP, recovery time
from sedation is shorter with propofol monotherapy
with no additional propofol dose requirement.