Official publication of Rawalpindi Medical University
Efficacy Of Tranexamic Acid in Reducing Blood Loss in Primary Total Knee Replacement

Supplementary Files

PDF

Keywords

Total knee replacement, Tranexamic acid, Efficacy.

How to Cite

1.
Younas MI, Rauf F, Mustafa MS, Janjua SN, Iqbal S, Habib K. Efficacy Of Tranexamic Acid in Reducing Blood Loss in Primary Total Knee Replacement. JRMC [Internet]. 2023 Jun. 24 [cited 2024 Apr. 16];27(2). Available from: http://www.journalrmc.com/index.php/JRMC/article/view/2064

Abstract

Objective: To determine the efficacy of tranexamic acid in reducing blood loss in primary total knee replacement.

Material and Methods: A total of 96 patients having a diagnosis of primary knee osteoarthritis made up the population sample. The Total Knee Replacement patients were separated into two groups. Patients in Group B used Intra venous tranexamic acid, but those in Group A did not use tranexamic acid during the course of the operation or afterwards.

Results: Mean age of the patients recorded in group A 63.79±6.60 (years) and in group B 62.96±7.89 (years). The majority of the patients in both groups were females. After surgery, Group B patients who received tranexamic acid reported less blood loss and less haemoglobin reduction as compared to the control group.

Conclusion: From our study, we conclude that Tranexamic acid used intravenously during total knee arthroplasty considerably lowers postoperative blood loss.

https://doi.org/10.37939/jrmc.v27i2.2064

References

Song K, Pan P, Yao Y, Jiang T, Jiang Q. The incidence and risk factors for allogenic blood transfusion in total knee and hip arthroplasty. J Orthop Surg Res. 2019;14(1):1-6. DOI: 10.1186/s13018-019-1271-7.

Pawaskar A, Salunke AA, Kekatpure A, Chen Y, Nambi GI, Tan J, et al. Do autologous blood transfusion systems reduce allogeneic blood transfusion in total knee arthroplasty? Knee Surg Sports Traumatol. Arthrosc. 2017;25(9):2957-66. DOI: 10.1007/s00167-016-4286-4.

Pechlivani N, Kearney KJ, Ajjan RA. Fibrinogen and Antifibrinolytic Proteins: Interactions and Future Therapeutics. Int J Mol Sci. 2021;22(22):12537. DOI:10.3390/ijms222212537

Li MM, Kwok JY, Chung KY, Cheung KW, Chiu KH, Chau WW, et al. Prospective randomized trial comparing efficacy and safety of intravenous and intra-articular tranexamic acid in total knee arthroplasty. Knee Surg Relat Res. 2020;32(1):1-6. DOI:10.1186/s43019-020-00007-2

Ye W, Liu Y, Liu WF, Li XL, Fei Y, Gao X. Comparison of efficacy and safety between oral and intravenous administration of tranexamic acid for primary total knee/hip replacement: a meta-analysis of randomized controlled trial. J Orthop Surg Res. 2020;15(1):1-1. DOI:10.1186/s13018-020-02115-1

Prakash J, Seon JK, Park YJ, Jin C, Song EK. A randomized control trial to evaluate the effectiveness of intravenous, intra-articular and topical wash regimes of tranexamic acid in primary total knee arthroplasty. J Orthop Surg Res. 2017;25(1):2309499017693529. DOI: 10.1186/s13018-017-0678-6

Duncan CM, Gillette BP, Jacob AK, Sierra RJ, Sanchez-Sotelo J, Smith HM. Venous thromboembolism and mortality associated with tranexamic acid use during total hip and knee arthroplasty. J Arthroplasty. 2015;30:272-6. DOI:10.1016/j.arth.2014.09.019

Sadigursky D, Andion D, Boureau P, Ferreira MC, Carneiro RJ, Colavolpe PO. Effect of tranexamic acid on bleeding control in total knee arthroplasty. Acta Ortopédica Brasileira. 2016 May;24:131-6. DOI: 10.1590/1413-785220162404159047

Irwin A, Khan SK, Jameson SS, Tate RC, Copeland C, Reed MR. Oral versus intravenous tranexamic acid in enhanced recovery primary total hip and knee replacement: results of 3000 procedures. Bone Joint J. 2013;95:1556-61. DOI:10.1302/0301-620X.95B11.32001

Aslam KS, Niazi AK, Nabi O. Efficacy of tranexamic acid in reducing blood loss in total knee replacements. J Pak Med Assoc. 2015;65(3):210-14 DOI: 10.1542/peds.2014-0131B

Slover J, Lavery JA, Schwarzkopf R, Iorio R, Bosco J, Gold HT. Incidence and Risk Factors for Blood Transfusion in Total Joint Arthroplasty: Analysis of a Statewide Database. J Arthroplasty. 2017;32(9):2684–2687.e1. DOI: 10.1016/j.arth.2017.04.020

Shander A, Hofmann A, Ozawa S, Theusinger OM, Gombotz H, Spahn DR. Activity-based costs of blood transfusions in surgical patients at four hospitals. Transfusion. 2010;50(4):753–65. DOI:10.1111/j.1537-2995.2009.02247.x

Stanworth SJ, Cockburn HAC, Boralessa H, Contreras M. Which groups of patients are transfused? A study of red cell usage in London and Southeast England. Vox Sang. 2002;83(4):352–7. DOI:10.1159/000065630

Kim TK, Chang CB, Kang YG, Seo ES, Lee JH, Yun JH, et al. Clinical value of tranexamic acid in unilateral and simultaneous bilateral TKAs under a contemporary blood-saving protocol: a randomized controlled trial. Knee Surg Sports Traumatol Arthrosc. 2014;22(8):1870-8. DOI: 10.1007/s00167-013-2426-7

Kakar PN, Gupta N, Govil P, Shah V. Efficacy and safety of tranexamic acid in control of bleeding following TKR: a randomized clinical trial. Indian J Anaesth. 2009;53(6):667-71. DOI:10.4103/0019-5049.146676

Roy SP, Tanki UF, Dutta A, Jain SK, Nagi ON. Efficacy of intra-articular tranexamic acid in blood loss reduction following primary unilateral total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc. 2012;20(12):2494-501. DOI:10.1007/s00167-011-1494-y

Pachauri A, Acharya KK, Tiwari AK. The effect of tranexamic acid on hemoglobin levels during total knee arthroplasty. Am J Ther. 2014;21(5):366-70. DOI:10.1097/MJT.0b013e318292d18e

Delanois RE, Mont MA. Does tranexamic acid reduce blood loss in total knee arthroplasty? Commentary on an article by X. Aguilera, MD, et al.:"Efficacy and safety of fibrin glue and tranexamic acid to prevent postoperative blood loss in total knee arthroplasty. A randomized controlled clinical trial". J Bone Joint Surg Am. 2013;95(22):e179. DOI: 10.2106/JBJS.M.00836

Chimento GF, Huff T, Ochsner JL Jr, Meyer M, Brandner L, Babin S. An evaluation of the use of topical tranexamic acid in total knee arthroplasty. J Arthroplasty. 2013;28(8 Suppl):74-7. DOI: 10.1016/j.arth.2013.05.023

Tan J, Chen H, Liu Q, Chen C, Huang W. A meta-analysis of the effectiveness and safety of using tranexamic acid in primary unilateral total knee arthroplasty. J Surg Res. 2013;184(2):880-7. DOI: 10.1016/j.jss.2013.04.017

Poeran J, Chan JJ, Zubizarreta N, Mazumdar M, Galatz LM, Moucha CS. Safety of tranexamic acid in hip and knee arthroplasty in high-risk patients. Anesthesiol. 2021;135(1):57-68. DOI: 10.1097/ALN.0000000000003723

Fan D, Ma J, Liu X, Zhang L. Peri-articular administration of tranexamic acid is an alternative route in total knee arthroplasty: a systematic review and meta-analysis. J Orthop Surg Res. 2022;17(1):1-21. DOI:10.1186/s13018-021-02820-9

Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Copyright (c) 2023 Muhammad Inaamullah Younas