Official publication of Rawalpindi Medical University
Frequency of Meningitis in Neonatal Sepsis

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Frequency, Meningitis, Late onset sepsis, Pre-term, Low body weight, Neonates.

How to Cite

Anjum A, Malik Q, Nadeem T, Ullah N, Ikram F, Hussain M. Frequency of Meningitis in Neonatal Sepsis. JRMC [Internet]. 2023 Apr. 1 [cited 2024 Jun. 15];27(1). Available from:


Objective: The aim of current study was to examine the frequency of meningitis in infants having late onset sepsis (LOS). Bacterial sepsis and meningitis endure to be leading causes of illness and mortality in neonates around the world, predominantly in preterm neonates. They must be discovered and cured as soon as possible to avoid death or disability.

Study Design: The Cross-Sectional method was used to conduct a study.

Duration and Place of Study: The study period was July to December 2021. Data was collected from Pak Emirates Military Hospital (PEMH) NICU Rawalpindi.

Material and Method: The study comprised a total of 110 individuals, both male and female. All of them were older than 3 days and had been hospitalized and diagnosed with late onset sepsis. A neonate was diagnosed with meningitis if his or her cerebrospinal fluid (CSF) had > 30 leukocytes/mm3 and any of these two: >200 mg/dl protein or 40 mg/dl glucose.

Results: Out of 110 infants having LOS 38 were diagnosed with meningitis in which 21(55.2%) were male and 17(44.8%) were female. Overall mean weight of neonates was 2.38±1.72. A total of 24(63.1%) having low body weight and 22(57.8%) were premature. Meningitis was found to have a significant association with low bod weight and pre-term birth (p value<0.05).

Conclusion: Meningitis was considerably high in neonates with (LOS). Low body weight and pre-term birth had significant association with meningitis having (LOS).


Aletayeb, SM., Khosravi, AD., Dehdashtian, M., Kompani, F., Mortazavi, SM., & Aramesh MR (2011). Identification of bacterial agents and antimicrobial susceptibility of neonatal sepsis: A 54-month study in a tertiary hospital. African J Microbial Res. (5):528-31.doi:

Bhagat, R., Hussain, SQ., Gattoo, IA., & Wani, SA., (2015).Incidence of meningitis in late onset sepsis. Contempt Pediatric, 2, 96-102. doi:

Camacho-Gonzalez, A., Spearman, PW., & Stoll, BJ., (2013) Neonatal infectious diseases: Evaluation of neonatal sepsis. Pediatric Clinics of North America. 60:367-389. doi: 10.1016/j.pcl.2012.12.003

Cantey, JB., & Milstone, AM., Bloodstream infections: Epidemiology and resistance. Clinics in Perinatology, 42:1-16. DOI: 10.1016/j.clp.2014.10.002

da Silva, LP., Cavalheiro, LG., Queirós, F., Nova, CV., & Lucena, R., (2007). Prevalence of newborn bacterial meningitis and sepsis during the pregnancy period for public health

care system participants in Salvador, Bahia, Brazil. Brazil journal of Infect Disease, 11,272. doi: 10.1590/s1413-86702007000200021

Furyk, JS., Swann, O., & Molyneux E.,(2011) . Systematic review: Neonatal meningitis in the developing world. Tropical Medicine & International Health. , 16, 672-679.

Ganatra, HA., Stoll, BJ., & Zaidi AK.,(2010). International perspective on early-onset neonatal sepsis. Clinics in Perinatology. , 37, 501-523. DOI: 10.1016/j.clp.2010.02.004

Grandgirard, D., & Leib, SL., (2010). Meningitis in neonates: Bench to bedside. Clinics in Perinatology. , 37, 655-676. DOI: 10.1016/j.clp.2010.05.004

Heath, PT., & Okike, IO., (2010). Neonatal bacterial meningitis: An update. Pediatrics and Child Health, 20, 526-530.

Jha, AK., & Jaiswal, AK., (2019). Assessment of occurrence of the meningitis in neonates with late onset sepsis admitted to Patna Medical College and Hospital, Patna. International Journal of Medical and Health Research, 5(4),122.

Kaul, V., Harish, R., Ganjoo, S., Mahajan, B., Raina, SK., & Koul, D., (2013). Importance of Obtaining Lumbar Puncture in Neonates with Late Onset Septicemia a Hospital Based Observational Study from North-West India. Clinic Neonate. ,2(2),83. • DOI: 10.4103/2249-4847.116407

Laving, AM., Musoke, RN., Wasunna, AO., & Revathi G., (2003). Neonatal bacterial meningitis at the newborn unit of Kenyatta National Hospital. East Afr Med, 80, 456-62. DOI: 10.4314/eamj.v80i9.8742

Longe, AC., Omene, JA.,& Okolo, AA., (1984). Neonatal meningitis in Nigerian infants. Acta Pediatriatic Scand., 73, 477-81. DOI: 10.1111/j.1651-2227.1984.tb09958.x

Nizet, V., & Klein, JO., (2016). Bacterial sepsis and meningitis. In: Wilson CB, Nizet V, Maldonado Y, editors. Remington and Klein’s Infectious Diseases of the Fetus and Newborn. 8th ed. Philadelphia: Elsevier Saunders; 217-271

Paulo, S., 2015.Segre CAM. Perinatology fundaments practice -3rd edn..

Polin, RA., & Harris, MC., (2001).Neonatal bacterial meningitis. Seminars in Neonatology ,6 ,157-172.

Roshi, B., Shiekh, QH., Imran, AG., & Shabir, AW., (2015). Incidence of meningitis in late onset. International Journal of Contemporary Pediatrics, 2, 2. doi:

Saleem S, Akbar N, Anwar A, Mehmood R. Frequency of Meningitis in

Neonatal Late Onset Sepsis in Gangaram Hospital, Lahore.APMC

2015;9(3):140-144. DOI:

Simonsen, KA., Anderson, AL., Delair, SF., & Davies HD (2014). Early-Onset Neonatal Sepsis. Clinical Microbiology Reviews. 2014;27(1):21-47. DOI:

Umate, S., Garg, BD., & Kabra, NS., (2019). Incidence of meningitis in neonates with late-onset sepsis at a Tertiary Care Center in Western India: An observational study. Clinic Neonates, 8, 67-70. DOI: 10.4103/jcn.JCN_64_18.

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Copyright (c) 2023 Akber Hussain, Qudratullah Malik, Muhammad Tariq Nadeem, Naem Ullah, Farooq Ikram, Murtaza Hussain