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Abstract
Objective: To assess status of bacterial pathogens in thalassemia major patients presenting with fever in a tertiary care hospital
Methods:
A retrospective descriptive study was conducted at –removed for blind review---from November, 2020 to October, 2021 in which 102 patients of thalassemia major who presented with fever and were suspicious of having septicemia were enrolled. Their demographic characteristics and pathological findings were noted in this study. Standardized approach was followed for blood withdrawal and sample collection required for performing blood cultures. The data was analyzed with SPSS version 21.
Results:
Females were in majority. Total 57 (56.0%) of patients had positive blood culture. The most frequent bacterial pathogen was Klebsiella pneumonia 13 (12.7%), followed by E-coli 11 (10.7%), staphylococcus aureus 7 (6.8%), pseudomonas 8 (7.8%) and streptococcus type pathogens 6 (5.8%).
Conclusion:
Positive culture findings were high in the thalassemia major patients who presented with fever.
References
Abu-Shaheen A, Heena H, Nofal A, Abdelmoety DA, Almatary A, Alsheef M, AlFayyad I. Epidemiology of Thalassemia in Gulf Cooperation Council Countries: A systematic Review. BioMed Research International 2020; Vol 2020; Article ID 1509501: 1-15 (https://doi.org/10.1155/2020/1509501)
Farrukh T. Shah, Farzana Sayani, Sara Trompeter, Emma Drasar, Antonio Piga. Challenges of blood transfusions in β-thalassemia. Blood Reviews 2019; 37: 100588. (https://doi.org/110.21037/aob-20-70)
Teawtrakul N, Jetsrisuparb A, Sirijerachai C, Chansung K, Wanitpongpun C. Severe bacterial infections in patients with non-transfusion-dependent thalassemia: prevalence and clinical risk factors. Int J Infect Dis 2015; 39: 53-56 (https://doi.org/10.1080/10245332.2017.1358845)
Khalid A, Siddiqui AJ, Ansari SH. Reflection of treatment proficiency of hydroxyurea treated β-thalassemia serum samples through nuclear magnetic resonance based metabonomics. Sci Rep 2019; 9: 2041 (https://doi.org/10.1038/s41598-019-38823-0)
Musharraf S, Iqbal A, Ansari S. β-Thalassemia Patients Revealed a Significant Change of Untargeted Metabolites in Comparison to Healthy Individuals. Sci Rep 2017; 7; 42249 (https://doi.org/10.1038/srep42249)
Kontoghiorghe CN, Kontoghiorghes GJ. Efficacy and safety of iron-chelation therapy with deferoxamine, deferiprone, and deferasirox for the treatment of iron-loaded patients with non-transfusion-dependent thalassemia syndromes. Drug Des Devel Ther. 2016;10:465-481. (https://doi.org/10.2147/DDDT.S79458)
Kiani RA, Anwar M, Waheed U, Asad MJ, Abbasi S, Zaheer HA. Epidemiology of
Transfusion Transmitted Infection among Patients with β-Thallassemia major in Pakistan. J Blood Transfusion 2016; Article ID 8135649: 1-5 (https://doi.org/10.1155/2016/8135649)
Jain R, Perkins J, Johnson ST, et al. A prospective study for prevalence and/or development of transfusion-transmitted infections in multiply transfused thallassemia major patients. Asian J Transfus Sci. 2012;6(2):151–154 (https://doi.org/10.4103/0973-6247.98919)
Al Badry BJ, Hussin AA, Abid IN, Jabber AS, Thmen AM. Bacterial Infections in Thallassemia major Patients at Thi-Qar Province/ South Iraq. American Scientific
Research Journal for Engineering, Technology, and Sciences (ASRJETS) 2016; 19: 199-205
Rahav G, Volach V, Shapiro M, Rund D, Rachmilewitz EA, Goldfarb A. Severe infections in Thalassemic patients: prevalence and predisposing factors. British Journal of Haematology 2006; 133: 667–674 (https://doi.org/10.1111/j.1365-2141.2006.06082.x)
Nithichanon A, Tussakhon I, Samer W. Immune responses in beta-thalassaemia: heme oxygenase 1 reduces cytokine production and bactericidal activity of human leucocytes. Sci Rep 2020; 10: 10297 (https://doi.org/10.1038/s41598-020-67346-2)
Dumaidi K, Al-Jawbreh A, Samarah F, Rabayaa M. Prevalence of Sero-Molecular
Markers of Hepatitis C and B Viruses among Patients with β-Thallassemia major in Northern West Bank, Palestine. Canadian Journal of Infectious Diseases and Medical Microbiology 2018; Article ID 1039423:1-6 (https://doi.org/10.1155/2018/1039423)
Ricerca BM, Girolamo AD, Rund D. Infections in Thallassemia major and Hemoglobinopathies: Focus on Therapy-Related Complications. Mediterr J Hematol Infect Dis. 2009; 1(1): e2009028. (https://doi.org/110.4084/MJHID.2009.028)
Saliba AN, Atoui A, Labban M. Thalassemia in the emergency department: special considerations for a rare disease. Ann Hematol 2020; 99: 1967–1977 (https://doi.org/10.1007/s00277-020-04164-6)
Said YM. Thalassemia Major: Transplantation or Transfusion and Chelation. Hematology/Oncology and Stem Cell Therapy 2017; 10: 290-298. (https://doi.org/10.1016/j.hemonc.2017.05.022)
Llor C, Bjerrum L. Antimicrobial resistance: risk associated with antibiotic overuse and initiatives to reduce the problem. Ther Adv Drug Saf 2014; 5(6): 229–241. (https://doi.org/110.1177/2042098614554919)
Koji, E.M., Gebretekle, G.B. & Tekle, T.A. Practice of over-the-counter dispensary of antibiotics for childhood illnesses in Addis Ababa, Ethiopia: a simulated patient encounter study. Antimicrob Resist Infect Control 2019; 8: 119 (https://doi.org/10.1186/s13756-019-0571-x)
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