Official publication of Rawalpindi Medical University
Effect of chronic restraint stress on body weight of male Sprague Dawley rats

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Keywords

Body weight, Chronic stress, cortisol

How to Cite

1.
Moazzam S, Mughal IA, Irfan NUA, Attique I, Zaheer F, Irfan A. Effect of chronic restraint stress on body weight of male Sprague Dawley rats. JRMC [Internet]. 2023 Apr. 2 [cited 2023 Jun. 5];27(1). Available from: http://www.journalrmc.com/index.php/JRMC/article/view/1848

Abstract

Background: 

Stress disturbs body weight and food intake, but the core mechanisms are not well understood. 

 

Study design:  Experimental  

 

Materials and Methods: 

The study was conducted in  National  Institute  of  Health  (NIH),  Islamabad Sixty male Sprague Dawley rats (mean wt 250 ± 50 grams) were used and divided into 2 groups.  

Each group comprised of 30 rats.  

Group I was taken as control. Group II was exposed to chronic stress. 

Results

The comparison of weight gain by the different groups disclosed that there was a significant decrease in weight gain of rats exposed to the chronic stress as compared to control group.  

 

Conclusion: 

Chronic restraint stress has a detrimental effect on body weight.  

https://doi.org/10.37939/jrmc.v27i1.1848

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Copyright (c) 2023 Sadia Moazzam, Irfan Afzal Mughal, Noor-ul-Ain Irfan, Ilqa Attique, Fareeha Zaheer, Asma Irfan