Case report of Nasopharyngeal Angiofibroma in a teenager female, a rare finding
Background: Angiofibroma is a rare histologically benign tumor that is an unencapsulated, highly vascular tumor.1 It shows very aggressive behavior due to local invasiveness and is associated with various symptoms.2 Angiofibroma is almost always seen in young adolescent males.2 Along main pathogenesis is unknown, but it is considered to be associated with sex hormones mainly testosterone and estradiol.3 In a study conducted from 1995 to 2012 all patients were male.4 Major symptoms include nasal obstruction and epistaxis and surgical removal of the tumor as a whole is considered the treatment of choice.5
There have been very few individual case reports of angiofibroma in females 6-9 which were confirmed with radiological testing and histopathology report of the samples taken.
Case presentation: We present a rare case of nasopharyngeal angiofibroma in a young female as confirmed by computed tomography scan findings and histopathology reports of the sample by well-qualified pathologists.
Conclusion: The case is being reported to increase awareness among medical professionals and encouraging further workup on the pathogenesis of angiofibroma.
2. Martins MB, de Lima FV, Mendonca CA, de Jesus EP, Santos AC, Barreto VM, et al. Nasopharyngeal angiofibroma: Our experience and literature review. International archives of otorhinolaryngology. 2013;17(1):14-9.
3. Kumagami H. Sex hormones in juvenile nasopharyngeal angiofibroma tissue. Auris, nasus, larynx. 1993;20(2):131-5.
4. Huang Y, Liu Z, Wang J, Sun X, Yang L, Wang D. Surgical management of juvenile nasopharyngeal angiofibroma: analysis of 162 cases from 1995 to 2012. The Laryngoscope. 2014;124(8):1942-6.
5. Zhang HK, Wang JJ, Liu ZF, Wang DH. Management of nasopharyngeal angiofibroma in a 72-year-old male through a sublabial and buccolabial incision approach: A case report and literature review. Oncology letters. 2015;10(3):1267-70.
6. Szymanska A, Korobowicz E, Golabek W. A rare case of nasopharyngeal angiofibroma in an elderly female. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies. 2006;263(7):657-60.
7. Osborn DA, Sokolovski A. Juvenile nasopharyngeal angiofibroma in a female. Report of a case. Archives of otolaryngology. 1965;82(6):629-32.
8. Madhavan Nirmal R, Veeravarmal V, Santha Devy A, Ramachandran CR. Unusual presentation of nasopharyngeal (juvenile) angiofibroma in a 45 year old female. Indian journal of dental research : official publication of Indian Society for Dental Research. 2004;15(4):145-8.
9. Finerman WB. Juvenile nasopharyngeal angiofibroma in the female. AMA archives of otolaryngology. 1951;54(6):620-3.
10. Wenig BM. Angıofıbroma (juvenile nasopharyngeal angiofibroma) In: Atlas Of Head And Neck Pathology 2008.
Copyright (c) 2021 Sundas Masood, Nausheen Qureshi, Fatima Shahid, Memoona Afzal, Aeimen Fatima, Asmara Hussain
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
All research articles published in the Journal of Rawalpindi Medical College (JRMC) are fully open access: immediately freely available to read, download, and share. Copyrights of all articles published in JRMC are retained by the authors. First publication rights are granted to JRMC. The journal/publisher is not responsible for subsequent uses of the work.
All articles are published under the Creative Commons Attribution (CC BY-SA 4.0) license.