Histopathological Typing and Topographic Distribution of Head and Neck Lesions: An Eight Year Retrospective Study

  • Fatima Iqbal Peshawar Dental College
  • Saleha Saeed Peshawar Dental College
  • Nasiha Bashir Peshawar Dental College
  • Sana Mushtaq Khattak Khyber College of Dentistry
  • Tehmina Naushin Peshawar Dental College
  • Muhammad Sulaiman Khyber College of Dentistry
Keywords: Head and Neck, Histopathology, Benign tumors, Malignant tumors.


Objective: To analyze the histopathological pattern of head and neck lesions with respect to demographic findings referred to the histopathology lab of Peshawar Medical College (PMC).

Study Design: Descriptive cross-sectional study.

Place and Study duration: Histopathology laboratory of PMC, Peshawar, Pakistan. Jan 2010 to Dec 2018.

Materials and Methods: A retrospective study was conducted on a total of 743 specimens submitted to the histopathology lab for diagnosis. Variables like age, gender, site, and histopathological spectrum were evaluated. Statistical Package for Social Sciences (SPSS) version 19 was used for descriptive and inferential statistics considering p-value ≤0.05 significant.

Results: In our study <30 age group was common for head and neck lesions. Females were frequently affected than males. A maximum number of diagnosed lesions was benign in nature with goiter as the most common lesion. Oral squamous cell carcinoma (OSCC) was a widespread malignant neoplasm. According to the site, the thyroid showed 36%of lesions followed by 9.5% lip and oral cavity and lymph nodes respectively.

Conclusion: This study concluded a variety of head and neck lesions with respect to age, gender, and site in our region that can help in improved understanding, management, and control of the disease.

Author Biographies

Saleha Saeed, Peshawar Dental College

Oral Pathology


Nasiha Bashir, Peshawar Dental College

Oral Pathology

Assistant Professor

Sana Mushtaq Khattak, Khyber College of Dentistry

Oral and Maxillofacial Surgery


Tehmina Naushin, Peshawar Dental College

Oral Pathology

Assistant Professor

Muhammad Sulaiman, Khyber College of Dentistry

Oral and Maxillofacial Surgery

Post Graduate Resident


1. Boyle P, Levin B. World cancer report 2008: IARC Press, International Agency for Research on Cancer; 2008.
2. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians. 2018;68(6):394-424. DOI: 10.3322/caac.21492.
3. Ali J, Sabiha B, Jan HU, Haider SA, Khan AA, Ali SS. Genetic etiology of oral cancer. Oral oncology. 2017;70:23-8. DOI: 10.1016/j.oraloncology.2017.05.004.
4. Shaw R, Beasley N. Aetiology and risk factors for head and neck cancer: United Kingdom National Multidisciplinary Guidelines. The Journal of Laryngology & Otology. 2016;130(S2):S9-S12. doi: 10.1017/S0022215116000360
5. Dhull AK, Atri R, Dhankhar R, Chauhan AK, Kaushal V. Major risk factors in head and neck Cancer: a retrospective analysis of 12-year experiences. World journal of oncology. 2018;9(3):80. doi: 10.14740/wjon1104w.
6. Lei F, Chen P-H, Chen J-Y, Wang W-C, Lin L-M, Huang H-C, et al. Retrospective study of biopsied head and neck lesions in a cohort of referral Taiwanese patients. Head & face medicine. 2014;10(1):28. https://doi.org/10.1186/1746-160X-10-28.
7. Urooj A, Mirza T, Agha MA, Rasool S. Frequency of head and neck lesions according to histopathologic diagnosis. Journal of the Dow University of Health Sciences (JDUHS). 2011;5(2):70-3. https://www.jduhs.com/index.php/jduhs/article/view/42.
8. Khiavi MM, Haghi-Ashtiani MT, Kharazi-Fard M-J, Kalantar R. Frequency of Head and Neck Masses in Iranian Children During a 21-Year Period. Iranian Journal of Pediatrics. 2018;28(6). DOI : 10.5812/ijp.64087.
9. Sharma S. Study of Pathological Spectrum of Neck Lesions with Cytohistopathological Correlation Namrata Sharma, Sangeeta Sharma, Mahuya Sarkar, Rani Bans al, An jali Khare, DAVENDRA SWARU P, Priya Gupta, Mitali Singhal. 2016. DOI: 10.7860/NJLM/2016/20415.2147.
10. de Arruda JAA, de Oliveira Silva LV, de Oliveira CdNA, Schuch LF, Batista AC, Costa NL, et al. A multicenter study of malignant oral and maxillofacial lesions in children and adolescents. Oral Oncology. 2017;75:39-45. DOI: 10.1016/j.oraloncology.2017.10.016.
11. Xavier Santos RL, da Silva Júnior EZ, Aroucha Lyra MC, Ribeiro de Andrade RA, Vilela Heimer M, de Souza Andrade ES. Oral and maxillofacial lesions in children and adolescents. Revista Cubana de Estomatología. 2018;55(4):1-9.
12. Amadeu JK, Schussel JL, Piazzetta CM, Torres-Pereira CC, Amenábar JM. Oral and maxillofacial complex lesions in adolescents: A retrospective study of 20 years. Int J Odontostomat. 2015;9(1):113-8.
13. Abdal K, Mostafazadeh S, Darvishi M. The frequency of tumors of the head and neck in a 10-year period in Ilam, Iran. Journal of Basic Research in Medical Sciences. 2018;5(4):22-7. http://dx.doi.org/10.29252/jbrms.5.4.22.
14. Agarwal S, Agrawal R, Gupta P, Kumar P. Distribution of head and neck lesions diagnosed on histopathology in Western UP: A retrospective study. Indian Journal of Pathology and Oncology. 2018;5(1):123-9.DOI: 10.18231/2394-6792.2018.0022.
15. Tomar YS, Lahari P, Agrawal P, Singh UR. A ONE YEAR RETROSPECTIVE STUDY OF HISTOPATHOLOGICAL LESIONS OF HEAD AND NECK. International Journal of Advanced Research. 2019;7(11):798-801. DOI: 10.21474/IJAR01/10076.
16. Irani S, BIDARI ZF, Sabeti S. Prevalence of pathological entities in neck masses: A study of 1208 consecutive cases. 2016. doi: 10.17795/ajdr-25614.
17. Moro JdS, Maroneze MC, Ardenghi TM, Barin LM, Danesi CC. Câncer de boca e orofaringe: epidemiologia e análise da sobrevida. Einstein (São Paulo). 2018;16(2). DOI: 10.1590/S1679-45082018AO4248.
18. Sharma M, Sharma A, Gandhi S, Khajuria A, Goswami K. Histopathological patterns of head and neck lesions-a two year retrospective hospital study. International Journal of Research in Medical Sciences. 2017;5(4):1-6. DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20171025.
19. Alam MS, Siddiqui SA, Perween R. Epidemiological profile of head and neck cancer patients in Western Uttar Pradesh and analysis of distributions of risk factors in relation to site of tumor. Journal of cancer research and therapeutics. 2017;13(3):430. DOI: 10.4103/0973-1482.180687.
20. Pandey A, Bhardwaj A, Maithani T, Kishore S, Singh V. Distributive analysis of Head and neck Swellings with their cytopathological correlation. Int J Otorhinolaryngol Clin. 2016;8:89-96.
21. Patel F, Gonsai RN, Patel ML, Qureshi N, Vora M. A Retrospective study of 130 cases in all age group presented with palpable head and neck swelling. Tropical Journal of Pathology & Microbiology. 2018;4(4):319-23.
22. Azimi S, Mortazavi H, Tennant M, Kruger E, Rezaei B, Taheri JB, et al. Pattern of the head and the neck cancer in two geographically and socioeconomically different countries. Journal of Orofacial Sciences. 2017;9(1):43. DOI: 10.4103/0975-8844.207943.
23. Singhal U, Nanda A, Lamba S, Sethi D, Jain S. Histomorphological Spectrum of Head and Neck Lesions: A Three Year Retrospective Analysis. Recent Advances in Pathology & Laboratory Medicine. 2018;4(2):1-5. DOI: https://doi.org/10.24321/2454.8642.201805.
24. Fonseca MF-L. Oral and maxillofacial lesions in older individuals and associated factors: A retrospective analysis of cases retrieved in two different services. Journal of clinical and experimental dentistry. 2019;11(10):e921. DOI: 10.4317/jced.56194.
25. Torabi-Parizi M, Poureslami H, Torabi-Parizi S, Kalantari M. A retrospective study of children and adolescents oral and maxillofacial lesions over a 20-year period in Kerman, Iran. Journal of Oral Health and Oral Epidemiology. 2017;6(4):203-10.
26. Khan NF, Saeed M, Butt AK, Khan AA. Epidemiology of Head and Neck Neoplasm’s in Balochistan. J Pak Dent Assoc. 2017;26(03):119.
27. Alhindi NA, Sindi AM, Binmadi NO, Elias WY. A retrospective study of oral and maxillofacial pathology lesions diagnosed at the Faculty of Dentistry, King Abdulaziz University. Clinical, cosmetic and investigational dentistry. 2019;11:45. DOI https://doi.org/10.2147/CCIDE.S190092.
28. Anwer AW, Faisal M, Malik A, Jamshed A, Hussain R, Pirzada M. Head and neck cancer in a developing country-a hospital based retrospective study across 10 years from Pakistan. J Cancer Allied Specialties. 2018;3(4):S104. DOI: https://doi.org/10.37029/jcas.v3i4.158
How to Cite
Iqbal F, Saeed S, Bashir N, Khattak S, Naushin T, Sulaiman M. Histopathological Typing and Topographic Distribution of Head and Neck Lesions: An Eight Year Retrospective Study. JRMC [Internet]. 30Sep.2021 [cited 7Dec.2021];25(3):339-44. Available from: http://www.journalrmc.com/index.php/JRMC/article/view/1546