Comparison of Efficacy of Oral Dydrogesterone VS Intramuscular Progesterone in terms of duration of cessation of vaginal bleeding in women with Threatened Abortion

Abstract

Objective: To compare the efficacy of oral dydrogesterone vs intramuscular progesterone in terms of mean duration of bleeding cessation in women with threatened abortion
Methodology: In this Randomized Controlled Trial, 552 patients diagnosed as threatened miscarriage were enrolled per inclusion and exclusion criteria and randomly assigned to two groups. Group A received oral dydrogesterone 40 mg p/o stat and then 10 mg p/o twice daily. Group B received intramuscular progesterone 250 mg once a week. Treatment was continued till one week after bleeding stops. Patients were followed up by weekly visits and ultrasound was done on each visit to check viability of fetus. The duration of cessation of vaginal bleeding in days was calculated for each woman taking the first day of treatment as day 1. Data was analyzed using SPSS version 22. For categorical variables like gravidity, cessation of bleeding, frequencies along with percentages were calculated. For continuous variables like age of patient, gestational age, duration in days till bleeding stops, mean along with standard deviation was calculated. To compare the mean duration of bleeding cessation in both groups, independent sample t-test was applied and p-value <0.05 was considered statistically significant.
Results: Mean age of the patients in the study was 28.40+2.96 years. The means for gestational age and parity were 8.86+1.31 weeks and 0.87+0.97 respectively, whereas mean duration of cessation of bleeding was 8.12+1.41 days. Mean duration of cessation of bleeding in both the groups was 7.01+0.91 and 9.22+0.83 days respectively which was statistically significant (p-value 0.000).
Conclusion: The study concludes that mean duration of bleeding cessation in days was less in oral as compared to intramuscular progesterone group in women with threatened abortion.