Comparison of High Versus Low Intra-Peritoneal Carbon Dioxide Pressure on Abdominal Pain, Hemodynamic Symptoms and Liver Function Tests in Patients Undergoing Laparoscopic Cholecystectomy

Abstract

Background: To compare the intensity of
abdominal pain, hemodynamic symptoms and liver
function tests due to usage of low and high-pressure
CO2 in individuals undergoing laparoscopic
cholecystectomy (LC).
Methods: A randomized double blind clinical trial
was conducted on a sample of 60 patients who were
undergoing LC. Patients within the age limit of 20-70
years were incorporated in the study. Patients were
separated into 2 groups; the first group was
administered to a PaCO2 of 7-10 mmHg while the
second group was administered to a PaCO2 of 12-14
mmHg. The abdominal pain, liver function tests and
hemodynamic symptoms were checked. Data
analysis was done using SPSS version 19.0.
Results:A significant statistical variation (p< 0.05)
was seen among systolic blood pressure of the two
groups. Similarly a statistically significant variation
was observed among the mean of heart rates. The
mean heart rate of the high-pressure group was high
during surgery and 1 h after operation (P < 0.05).
High pressure group had high value of abdominal
pain.
Conclusion: Due to quality and less side effects,
low-pressure LC technique is better than high-
pressure laparoscopic cholecystectomy.