Comparison of Oral Azithromycin and Intra Venous Ceftriaxone for Treatment of Uncomplicated Enteric Fever in Children

  • Imran Khokar Department of Paediatrics, Railway Hosptial, and Islamic International Medical College, Rawalpindi
  • saba Afzal Department of Paediatrics, Railway Hosptial, and Islamic International Medical College, Rawalpindi
  • Samiya Naemullah Department of Paediatrics, Railway Hosptial, and Islamic International Medical College, Rawalpindi

Abstract

Background : To compare the clinical efficacy of
intravenous (I/V) Ceftriaxone with oral
Azithromycin in 2-12 year old children diagnosed
with enteric fever.

Methods: In this comparative study children with
the history of fever for >4 days and at least two out
of these findings, i.e., toxic physical appearance,
abdominal pain, coated tongue, hepatomegaly,
splenomegaly were divided into two equal groups.
Patients in Group A were given Azithromycin 20 mg
/ kg/ day as a single oral dose whereas patients in
Group B were given Ceftriaxone 100 mg/kg/day as a
single I/V injection for 07 days. Before initiation of
therapy samples for Typhidot and Widal test were
collected and only those testing positive were
included.
Results: There were 42 (93.3%) and 40 (88.9%)
patients in both the groups respectively who were
clinically cured. No significant difference was found
between these two groups (p-value 0.459).
Conclusion: There was no difference in the
clinical efficacy between Ceftriaxone and
Azithromycin for the treatment of typhoid fever in
children.

Published
2019-05-02
How to Cite
1.
Khokar I, Afzal saba, Naemullah S. Comparison of Oral Azithromycin and Intra Venous Ceftriaxone for Treatment of Uncomplicated Enteric Fever in Children. JRMC [Internet]. 2May2019 [cited 7Jul.2020];23(2):64-7. Available from: http://www.journalrmc.com/index.php/JRMC/article/view/1097
Section
Articles